Öz
Background: It is well known that patients with high serum ferritin levels are associated with specific clinical conditions. In this study, we aimed to investigate the frequency and distribution of patients with retrospective serum ferritin levels> 1000 ng / L in a training and research hospital according to our hospital records.
Methods: Serum ferritin levels of patients who applied to Diyarbakır Gazi Yaşargil Training and Research Hospital between January-2016 and September-2019 were analyzed retrospectively.
Results: Of these patients, 323 (mean age: 57.4) had serum ferritin levels> 1000 ng / ml. 147 (45.5%) of these patients were male and 176 (54.5%) were female. The largest group was nephrology patients with 60.3%. The most common cause in this group was chronic renal failure (CRF). The second largest group was hematology (16.7%) and the third was oncology (10.8%).
Conclusions: In conclusion, although it is a non-specific disease marker, serum ferritin measurement is frequently requested in all hospitals. We believe that when extremely high ferritin values are detected, we should consider the most common, although it is necessary to keep in mind many important clinical conditions.
Anahtar Kelimeler
Kaynakça
- Wang W, Knovich MA, Coffman LG, Torti FM, Torti S V. Serum ferritin: Past, present and future. Vol. 1800, Biochimica et Biophysica Acta - General Subjects. 2010. p. 760–9.
- Kernan KF, Carcillo JA. Hyperferritinemia and inflammation. Int Immunol. 2017;29(9):401–9.
- Jehn M, Clark JM, Guallar E. Serum ferritin and risk of the metabolic syndrome in U.S. adults. Diabetes Care. 2004 Oct;27(10):2422–8.
- Crichton RR, charloteaux‐wauters M. Iron transport and storage. Eur J Biochem. 1987;164(3):485–506.
- Gozzelino R, Soares MP. Coupling heme and iron metabolism via ferritin H chain. Vol. 20, Antioxidants and Redox Signaling. Mary Ann Liebert Inc.; 2014. p. 1754–69.
- Senjo H, Higuchi T, Okada S, Takahashi O. Hyperferritinemia: causes and significance in a general hospital. Hematology. 2018 Nov 26;23(10):817–22.
- Kernan KF, Carcillo JA. Hyperferritinemia and inflammation. Int Immunol 2017;29(9):401–9.
- Senturk Yikilmaz A, Akinci S, Bakanay ŞM, Dilek İ. In myelodysplastic syndrome cases, what should be the level of ferritin which has prognostic value? Transfus Clin Biol 2019 Nov;26(4):217-223.
- Epperly R, Furman W, Hines M, Santiago T, Li Y, Madden R, et al. Secondary hemophagocytic syndrome after autologous hematopoietic cell transplant and immune therapy for neuroblastoma. Pediatr Blood Cancer. 2019 Nov 1;66(11).
- Brierley CK, Revuelta Iniesta R, Storrar N, Thomas AE. Hyperferritinemia in Pediatric Acute Lymphoblastic Leukemia: What Does it Mean? Vol. 39, Journal of Pediatric Hematology/Oncology. Lippincott Williams and Wilkins; 2017. p. 238.
- Moris W, Verhaegh P, Jonkers D, Deursen C Van, Koek G. Hyperferritinemia in Nonalcoholic Fatty Liver Disease: Iron Accumulation or Inflammation? Semin Liver Dis. 2019;39(4):476–82.
- Sackett K, Cunderlik M, Sahni N, Killeen AA, Olson APJ. Extreme hyperferritinemia: Causes and impact on diagnostic reasoning. Am J Clin Pathol. 2016 May 1;145(5):646–50.
Öz
Amaç: Serum ferritin düzeyinin yüksek olduğu hastaların özel klinik durumlarla birlikte olduğu iyi bilinmektedir. Çalışmamızda bir eğitim ve araştırma hastanesinde retrospektif serum ferritin düzeyi >1000 ng/L olan hastaların hastane kayıtlarımıza göre sıklığı ve kliniklere göre dağılımını araştırmayı amaçladık.
Materyal ve metod: Ocak-2016 ve Eylül-2019 tarihleri arasında Diyarbakır Gazi Yaşargil Eğitim Araştırma hastanesine başvuran hastalardan istenilen serum ferritin düzeyleri retrospektif olarak incelendi. Serum ferritin düzeyi >1000 ng/L üzerindeki sonuçlar ayrıca değerlendirmeye alındı. Demografik bilgiler ve medikal hasta kayıtları, ilgili kliniklerle ortak çalışılarak değerlendirildi.
Bulgular: Bu hastalardan 323 ‘ünde ( yaş ortalaması:57,4) serum ferritin düzeyi > 1000 ng / ml dir. Bu hastaların 147’si erkek (%45,5), 176’si kadındı (%54,5). En büyük grup % 60,3 ile nefroloji hastalarıydı. Bu grup içinde en yaygın neden kronik böbrek yetmezliği (KBY) idi. İkinci en büyük grup, hematoloji(%16,7) üçüncü ise onkolojiydi (%10,8).
Sonuç: Spesifik olmayan hastalık belirteçi olmasına rağmen tüm hastanelerde sıkça serum ferritin ölçümü istenmektedir.Aşırı yüksek ferritin değerleri tesbit edildiğinde birçok önemli klinik durumları akılda tutmak gereksede en başta yaygın olanı düşünmemiz gerektiği kanaatindeyiz
Anahtar Kelimeler
Kaynakça
- Wang W, Knovich MA, Coffman LG, Torti FM, Torti S V. Serum ferritin: Past, present and future. Vol. 1800, Biochimica et Biophysica Acta - General Subjects. 2010. p. 760–9.
- Kernan KF, Carcillo JA. Hyperferritinemia and inflammation. Int Immunol. 2017;29(9):401–9.
- Jehn M, Clark JM, Guallar E. Serum ferritin and risk of the metabolic syndrome in U.S. adults. Diabetes Care. 2004 Oct;27(10):2422–8.
- Crichton RR, charloteaux‐wauters M. Iron transport and storage. Eur J Biochem. 1987;164(3):485–506.
- Gozzelino R, Soares MP. Coupling heme and iron metabolism via ferritin H chain. Vol. 20, Antioxidants and Redox Signaling. Mary Ann Liebert Inc.; 2014. p. 1754–69.
- Senjo H, Higuchi T, Okada S, Takahashi O. Hyperferritinemia: causes and significance in a general hospital. Hematology. 2018 Nov 26;23(10):817–22.
- Kernan KF, Carcillo JA. Hyperferritinemia and inflammation. Int Immunol 2017;29(9):401–9.
- Senturk Yikilmaz A, Akinci S, Bakanay ŞM, Dilek İ. In myelodysplastic syndrome cases, what should be the level of ferritin which has prognostic value? Transfus Clin Biol 2019 Nov;26(4):217-223.
- Epperly R, Furman W, Hines M, Santiago T, Li Y, Madden R, et al. Secondary hemophagocytic syndrome after autologous hematopoietic cell transplant and immune therapy for neuroblastoma. Pediatr Blood Cancer. 2019 Nov 1;66(11).
- Brierley CK, Revuelta Iniesta R, Storrar N, Thomas AE. Hyperferritinemia in Pediatric Acute Lymphoblastic Leukemia: What Does it Mean? Vol. 39, Journal of Pediatric Hematology/Oncology. Lippincott Williams and Wilkins; 2017. p. 238.
- Moris W, Verhaegh P, Jonkers D, Deursen C Van, Koek G. Hyperferritinemia in Nonalcoholic Fatty Liver Disease: Iron Accumulation or Inflammation? Semin Liver Dis. 2019;39(4):476–82.
- Sackett K, Cunderlik M, Sahni N, Killeen AA, Olson APJ. Extreme hyperferritinemia: Causes and impact on diagnostic reasoning. Am J Clin Pathol. 2016 May 1;145(5):646–50.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Orjinal Araştırma |
| Yazarlar | |
| Yayımlanma Tarihi | 15 Ocak 2021 |
| Yayımlandığı Sayı | Yıl 2020 Cilt: 29 Sayı: 6 |
