Öz
Aim: Recent studies have suggested that disruptions in the gut microbiota could potentially contribute to the pathogenesis of chronic pain and fibromyalgia syndrome (FMS) by affecting the gut microbiota-brain axis. The increasing prevalence of fibromyalgia syndrome has prompted investigations into the impact of probiotic food consumption, which regulates the microbiota, on quality of life.
Material and Methods: The study included 99 patients diagnosed with fibromyalgia syndrome who presented to our Physical Medicine and Rehabilitation outpatient clinic. A questionnaire was administered to assess the patients' knowledge and consumption of probiotic foods, and the Short Form-12 Health Survey(SF-12) was used to gather data and assess health-related quality of life.
Results: Of the 99 patients who completed the questionnaire, 89 were female and 10 were male. In response to the question, "Do you know what probiotics are?"7.4% of primary school graduates,64.7% of high school graduates, and 78.6% of university graduates answered affirmatively. When asked, "Have you experienced any benefits from probiotic foods?" 21.2% responded positively, and among those who experienced benefits, the most common accompanying issue (37.04%) was Irritable Bowel Syndrome(IBS). Fibromyalgia syndrome patients who consumed yogurt as a probiotic had higher physical function subdomain scores on the SF-12 Health Survey.
Conclusion: The high level of education in FMS patients increased the awareness of probiotics. Probiotic consumption may have a improving effect on irritable bowel syndrome and constipation associated with FMS.Training on probiotics and increasing the frequency of use of probiotics, the quality of life of FMS patients can be increased and accompanying symptoms can be reduced.
Anahtar Kelimeler
Kaynakça
- Foodinprogress.[Internet]. Canada: FAO/WHO: Guidelines forthe evaluation of probiotics in food. Joint Working Group Report on Drafting Guidelines for the Evaluation of Probiotics in Food. [Updated:2020 May 16; Cited 2022 Agust 8]. Avaliable from: https://www.foodinprogress.com/wp-content/uploads/2019/04/Guidelines-for-the-Evaluation-of-Probiotics-in-Food.pdf
- Pronio A, Montesani C, Butteroni C, Vecchione S, Mumolo G, Vestri A, et al. Probiotic administration in patients with ileal pouch-anal anastomosis for ulcerative colitis is associated with expansion of mucosal regulatory cells. Inflamm Bowel Dis. 2008; 14(5): 662-8.
- Yasui H, Shida K, Matsuzaki T, Yokokura T. Immunomodulatory function of lactic acid bacteria. Antonie van Leeuwenhoek. 1999;76(1):383-9.
- Kalliomaki M, Kirjavainen P, Eerola E, Kero P, Salminen S, Isolauri E. Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developed. J Allergy Clin Immunol. 2001; 107(1): 129-34.
- Isolauri E, Arvola T, Sütas Y, Moilanen E, Salminen S. Probiotics in the management of atopic eczema. Clin Exp Allergy. 2000; 30(11): 1604-10.
- Fao.org [Internet]. Report of the Joint FAO/WHO Expert Consultation on Evaluation of Health and Nutritional Properties of Probiotics in Food Including Powder Milk with Live Lactic Acid Bacteria. [Updated:2020 May 16; Cited 2022 Agust 8]. Avaliable from: https://www.fao.org/3/a0512e/a0512e.pdf
- Coşkun, T. Fonksiyonel bileşiklerin sağlığımız üzerine etkileri. Çocuk Sağlığı ve Hastalıkları Dergisi 2005; 48(1): 69-84.
- Balkış, M. Lise öğrencilerinin beslenme alışkanlıkları, probiyotik süt ürünleri tüketim sıklıkları ve bilgilerinin belirlenmesi: kulu örneği. [Master dissertation].Selcuk University; 2011.
- Bağdatlı AB, Kundakçı A. Fermente et ürünlerinde probiyotik mikroorganizmaların kullanımı. C.B.Ü. Fen Bilimleri Derg. 2013; 9(1): 31-7.
- Ford AC, Quigley EM, Lacy BE, Lembo AJ, Saito YA, Schiller LR, et al. Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis. Am J Gastroenterol. 2014; 109(10): 1547-61
- Ablin JN, Buskila D. Update on the genetics of the fibromyalgia syndrome.Best Pract Res Clin Rheumatol. 2015; 29(1): 20-8.
- Triadafilopoulos G, Simms RW, Goldenberg DL. Bowel dysfunction in fibromyalgia syndrome. Dig Dis Sci. 1991; 36(1): 59-64.
- Freidin MB, Stalteri MA, Wells PM, Lachance G, Baleanu AF, Bowyer RCE, et al. association between chronic widespread pain and the gut microbiome. Rheumatology 2020; 60(8): 3727-37.
- Erdrich S, Hawrelak JA, Myers SP, Harnett JE. Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review. BMC Musculoskelet. Disord. 2020; 181(2020): 1-12.
- Soylu C, Kütük B. SF-12 Yaşam Kalitesi Ölçeği’nin Türkçe formunun güvenirlik ve geçerlik çalışması. Türk Psikiyatri Derg. 2022; 33(2): 108-17.
- Babajimopoulos M, Fotiadou E, Alexandridou E, Nikolaidou AI. Consumer’s knowledge on probiotics and consumption of these products in the city of Thessaloniki, Greece, 9th Karlsruhe Nutrition Congress; 2004 Oct 10-12;Germany
- Aydın M, Açıkgöz İ, Şimşek B. Isparta Süleyman Demirel Üniversitesi öğrencilerinin probiyotik ürün tüketimlerinin ve probiyotik kavramının bilinme düzeyinin belirlenmesi. GTED. 2012; 5(2): 1-6.
- Al-Muammar MN, Ahmad SM, Mahboub SM, Fetohy and Elareefy AA, Feroze S. Behaviour of consumers towards probiotics containing products and its related factors. IJBPAS. 2013; 2(2): 208-19
- Anukam KC, Osazuwa EO, Reid, G. Knowledge of probiotics by Nigerian clinicians. Int J of Pro and Pre. 2006; (1): 57-62.
- Fernandez MA, Marette A. Potential health benefits of combining yogurt and fruits based on their probiotic and prebiotic properties. Adv Nutr. 2017; 8(1):155-64.
- El-Abbadi NH, Dao MC, Meydani SN. Yogurt: role in healthy and active aging.Am J Clin Nutr. 2014; 99(5): 1263-70.
- Minerbi A, Gonzalez E, Brereton NJB, Anjarkouchian A, Dewar K, Fitzcharles MA, et al. Altered microbiome composition in individuals with fibromyalgia. Pain 2019; 160(11): 2589-602.
Öz
Amaç: Bağısak mikrobiyotası düzensizlikler son zamanlarda yapılan çalışmalarda beyin bağırsak aksını bozarak kronik ağrı ve fibromiyalji sendromunun(FMS) nedeni olabileceği belirtilmiştir. Görülme sıklığı artan fibromiyalji sendromunda mikrobiyotayı düzenleyen probiyotik besin tüketiminin yaşam kalitesine etkisi araştırılmıştır.
Gereç ve Yöntemler: Çalışmaya hastanemiz Fiziksel Tıp ve Rehabilitasyon polikliniğine başvuran fibromiyalji sendromu tanısı konulmuş 99 hasta alındı. Çalışmada fibromiyalji hastalarına probiyotik besinler hakkında bilgi düzeyleri ve tüketim durumlarının belirlenmesi anketi, Kısa Form-12 Sağlık (SF-12) Ölçeği uygulandı ve veri olarak kullanıldı.
Bulgular: Anketi dolduran 99 fibromiyalji sendromu tanısı konulan hastaların 89’u kadın, 10’u erkek hastadan oluşmaktaydı. “Probiyotik nedir biliyor musunuz?” sorusuna ilkokul mezunları %7,4, lise mezunları %64,7, üniversite mezunları %78,6 oranında evet yanıtını verdi. “Probiyotik besinlerden fayda gördünüz mü?” sorusuna %21,2 evet cevabı verildi ve fayda görenlere en sık eşlik eden problem (%37,04) İrritabl Bağırsak Sendromu (İBS) idi. Probiyotik olarak yoğurt tüketen fibromiyalji sendromu olan hastaların SF-12 Sağlık Ölçeğinin fiziksel fonksiyon alt birim puanları daha yüksek saptandı.
Sonuç: Fibromiyalji sendromlu tanılı hastalarda eğitim seviyesinin yüksekliği probiyotik bilinirliğini arttırır. Fibromiyalji sendromuna eşlik eden irritabl bağırsak sendromu ve kabızlıkta probiyotik tüketimi iyileştirici etki gösterebilir. Bağırsak mikrobiyotasını düzenleyen probiyotikler hakkında eğitimler verilip, probiyotiklerin kullanım sıklığını arttırılarak fibromiyalji sendromu olan hastaların yaşam kalitesi artabilir, eşlik eden semptomlar azalabilir.
Anahtar Kelimeler
Kaynakça
- Foodinprogress.[Internet]. Canada: FAO/WHO: Guidelines forthe evaluation of probiotics in food. Joint Working Group Report on Drafting Guidelines for the Evaluation of Probiotics in Food. [Updated:2020 May 16; Cited 2022 Agust 8]. Avaliable from: https://www.foodinprogress.com/wp-content/uploads/2019/04/Guidelines-for-the-Evaluation-of-Probiotics-in-Food.pdf
- Pronio A, Montesani C, Butteroni C, Vecchione S, Mumolo G, Vestri A, et al. Probiotic administration in patients with ileal pouch-anal anastomosis for ulcerative colitis is associated with expansion of mucosal regulatory cells. Inflamm Bowel Dis. 2008; 14(5): 662-8.
- Yasui H, Shida K, Matsuzaki T, Yokokura T. Immunomodulatory function of lactic acid bacteria. Antonie van Leeuwenhoek. 1999;76(1):383-9.
- Kalliomaki M, Kirjavainen P, Eerola E, Kero P, Salminen S, Isolauri E. Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developed. J Allergy Clin Immunol. 2001; 107(1): 129-34.
- Isolauri E, Arvola T, Sütas Y, Moilanen E, Salminen S. Probiotics in the management of atopic eczema. Clin Exp Allergy. 2000; 30(11): 1604-10.
- Fao.org [Internet]. Report of the Joint FAO/WHO Expert Consultation on Evaluation of Health and Nutritional Properties of Probiotics in Food Including Powder Milk with Live Lactic Acid Bacteria. [Updated:2020 May 16; Cited 2022 Agust 8]. Avaliable from: https://www.fao.org/3/a0512e/a0512e.pdf
- Coşkun, T. Fonksiyonel bileşiklerin sağlığımız üzerine etkileri. Çocuk Sağlığı ve Hastalıkları Dergisi 2005; 48(1): 69-84.
- Balkış, M. Lise öğrencilerinin beslenme alışkanlıkları, probiyotik süt ürünleri tüketim sıklıkları ve bilgilerinin belirlenmesi: kulu örneği. [Master dissertation].Selcuk University; 2011.
- Bağdatlı AB, Kundakçı A. Fermente et ürünlerinde probiyotik mikroorganizmaların kullanımı. C.B.Ü. Fen Bilimleri Derg. 2013; 9(1): 31-7.
- Ford AC, Quigley EM, Lacy BE, Lembo AJ, Saito YA, Schiller LR, et al. Efficacy of prebiotics, probiotics, and synbiotics in irritable bowel syndrome and chronic idiopathic constipation: systematic review and meta-analysis. Am J Gastroenterol. 2014; 109(10): 1547-61
- Ablin JN, Buskila D. Update on the genetics of the fibromyalgia syndrome.Best Pract Res Clin Rheumatol. 2015; 29(1): 20-8.
- Triadafilopoulos G, Simms RW, Goldenberg DL. Bowel dysfunction in fibromyalgia syndrome. Dig Dis Sci. 1991; 36(1): 59-64.
- Freidin MB, Stalteri MA, Wells PM, Lachance G, Baleanu AF, Bowyer RCE, et al. association between chronic widespread pain and the gut microbiome. Rheumatology 2020; 60(8): 3727-37.
- Erdrich S, Hawrelak JA, Myers SP, Harnett JE. Determining the association between fibromyalgia, the gut microbiome and its biomarkers: A systematic review. BMC Musculoskelet. Disord. 2020; 181(2020): 1-12.
- Soylu C, Kütük B. SF-12 Yaşam Kalitesi Ölçeği’nin Türkçe formunun güvenirlik ve geçerlik çalışması. Türk Psikiyatri Derg. 2022; 33(2): 108-17.
- Babajimopoulos M, Fotiadou E, Alexandridou E, Nikolaidou AI. Consumer’s knowledge on probiotics and consumption of these products in the city of Thessaloniki, Greece, 9th Karlsruhe Nutrition Congress; 2004 Oct 10-12;Germany
- Aydın M, Açıkgöz İ, Şimşek B. Isparta Süleyman Demirel Üniversitesi öğrencilerinin probiyotik ürün tüketimlerinin ve probiyotik kavramının bilinme düzeyinin belirlenmesi. GTED. 2012; 5(2): 1-6.
- Al-Muammar MN, Ahmad SM, Mahboub SM, Fetohy and Elareefy AA, Feroze S. Behaviour of consumers towards probiotics containing products and its related factors. IJBPAS. 2013; 2(2): 208-19
- Anukam KC, Osazuwa EO, Reid, G. Knowledge of probiotics by Nigerian clinicians. Int J of Pro and Pre. 2006; (1): 57-62.
- Fernandez MA, Marette A. Potential health benefits of combining yogurt and fruits based on their probiotic and prebiotic properties. Adv Nutr. 2017; 8(1):155-64.
- El-Abbadi NH, Dao MC, Meydani SN. Yogurt: role in healthy and active aging.Am J Clin Nutr. 2014; 99(5): 1263-70.
- Minerbi A, Gonzalez E, Brereton NJB, Anjarkouchian A, Dewar K, Fitzcharles MA, et al. Altered microbiome composition in individuals with fibromyalgia. Pain 2019; 160(11): 2589-602.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Klinik Tıp Bilimleri (Diğer) |
| Bölüm | Araştırma Makaleleri |
| Yazarlar | |
| Yayımlanma Tarihi | 21 Eylül 2023 |
| Gönderilme Tarihi | 19 Ağustos 2023 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 13 Sayı: 3 |
