Öz
SARS CoV-2, konakçı hücrelerine girişi esas olarak solunum yolu endoteli, vasküler endoteli, renal hücreler ve ince bağırsak hücreleri yanında ACE 2 reseptörü üzerinden MSS’ye yayılım yapabileceği üzerinde durulmaktadır. Covid-19 pozitif viral pnomoni olan bir çok olguda ensefalit kliniği gelişmesi üzerine SARS CoV-2 de dahil olmak üzere nörolojik tutulumlar incelenmiştir. Covid 19 pandemi sürecinde Covid-19’un sadece basit bir alt solunum yolu enfeksiyonu ile kendini sınırlamayıp ciddi sistemik hastalığa neden olmakta ve sinir sistemini etkileyebildiğini göstermiştir. Bu yüzden pandemi sürecinde başvuran ve tüm Covid-19 tanısı alan hastalarda gelişebilecek nörolojik semptomlar açısından tetikte olunmalıdır.
Anahtar Kelimeler
SARS CoV-2 Covid-19 merkezi Sinir Sistem Nöroloji Nörolojik Belirti
Kaynakça
- 1. World Health Organization. Novel Coronavirus (2019-nCoV) technical guidance. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance (Accessed on February 14, 2020).
- 2 Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumo- nia in China. N Engl J Med 2020; 20:382-8. doi:10.1056/NEJMoa2001017
- 3.Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020; published online 3 February. doi:10.1038/s41586-020-2012-7
- 4. Jin H, Hong C, Chen S, et al. Consensus for prevention and management of coronavirus disease 2019 (COVID-19) for neurologists. Stroke and Vascular Neurology. 2020;0. doi: 10.1136/svn-2020-000382.
- 5.https://www.who.int/emergencies/diseases/novel-coro- navirus-2019.
- 6. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China 7. Ling Mao; Huijuan Jin; Mengdie Wang; Yu Hu; Shengcai Chen; Quanwei He; Jiang Chang; Candong Hong; Yifan Zhou; David Wang; Xiaoping Miao; Yanan Li, MD, PhD; Bo Hu, MD, PhD
- 8. Giacomelli et al., 2020; Ryan, 2020; Hopkins and Kumar, 2020
- 9.A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9 Mary Donoghue, Frank Hsieh, Elizabeth Baronas, Kevin Godbout, Michael Gosselin, Nancy Stagliano, Michael Donovan, Betty Woolf, Keith Robison, Raju Jeyaseelan, Roger E. Breitbart, Susan Acton
- 10. Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 Virus Targeting the CNS : Tissue Distributi- on , Host − Virus Interaction , and Proposed Neurotropic Mechanisms. ACS Chem. Neurosci. 2020, 11, 995−998
- 11.Al-Obaidi ve diğerleri, 2018; Soung ve Klein, 2018).
- 12 Li Y, Fu L, Gonzales DM, Lavi E. Coronavirus neurovirulence correlates with the ability of the virus to induce proinflammatory cytokine sig- nals from astrocytes and microglia. J Virol. 2004;78: 3398-406
- 13.Neurological complications of coronavirus and COVID-19. Carold-artal FJ1 DOI: 10.33588/rn.7009.2020179
- 14.Desforges M, Le Coupanec A, Dubeau P, Bourgouin A,Lajoie L, Dubé M, Talbot PJ. Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? Viruses. 2019;12. pii: E14.
- 15. How viruses infiltrate the central nervous system A. mıchalıcov.1, k. bhıde3, m. bhıde1,3, a. kov.č1,2*
- 16.Ye M, Ren Y, Lv T. Encephalitis as a clinical manifestation of COVID-19. Brain Behav Immun. 2020 Apr 10. pii: S0889- 1591(20)30465-7.
- 17.Moriguchi T, Harii N, Goto J, Harada D, Sug- awara H, Takamino J, et al. A first case of meningitis/encephalitis associated with SARS- Coronavirus-2. Int J Infect Dis. 2020;94:55-8
- 18. COVID-19–associated Acute Hemorrhagic Necrotizing Encephalopathy: CT and MRI Neo Poyiadji, MD, Gassan Shahin, MD, Daniel Noujaim, MD, Michael Stone, MD, Suresh Patel, MD, Brent Griffith, MD
- 19. Acute necrotizing encephalopathy and myocarditis in a young patient with COVID-19 Ahmed Elkady, MSc, and Alejandro A. Rabinstein, MD Neurol Neuroimmunol Neuroinflamm 2020;7:e801. doi:10.1212/NXI.0000000000000801
- 20.Wong PF, Craik S, Newman P, et al. Lessons of the month 1: a case of rhombencephalitis as a rare complication of acute COVID-19 infection. Clin Med (Lond) 2020; published online May 5. https://doi.org.10.7861/clinmed.2020-0182.
- 21) Zanin L, Saraceno G, Panciani PP, et al. SARS-CoV-2 can induce brain and spine demyelinating lesions. Acta Neurochir (Wien) 2020; published online May 4. https://doi.org.10.1007/s00701-020-04374-x.
- 22. Li M, Wang M, Zhou Y, Sapozhnikov S, Dandu V, Toom S. et al. Acute cerebrovascular disease following CO- VID-19 : a single center , retrospective , observational study. The Lancet. 2020;19. Online ahead of print.
- 23. Beyrouti R, Adams ME, Benjamin L, Cohen H, Farmer SF, Goh YY, et al. Characteristics of ischaemic stroke associated with COVID-19. J Neurol Neurosurg Psychiatry. 2020.
- 24. Oxley TJ, Mocco J, Majidi S, Kellner CP, Shoirah H, Singh IP, et al. Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young. N Engl J Med. 2020 May;382(20):e60.
Öz
SARS CoV-2, can spread to Central Nervous system via the ACE 2 receptor as well as the respiratory tract endothelium, vascular endothelium, renal cells and small intestine cells. In many cases with Covid-19 positive viral pneumonia, neurological involvements were investigated upon the development of the encephalitis clinic. In the Covid 19 pandemics, Covid-19 does not limit itself to only a simple lower respiratory tract infection, but it has been shown to cause serious systemic disease and affect the nervous system. Therefore, during the pandemic, patients diagnosed with Covid-19 should be alerted in terms of neurological symptoms.
Anahtar Kelimeler
SARS CoV-2 COVID 19 Central Nervous System Neurology Neurological Symptom
Kaynakça
- 1. World Health Organization. Novel Coronavirus (2019-nCoV) technical guidance. https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance (Accessed on February 14, 2020).
- 2 Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumo- nia in China. N Engl J Med 2020; 20:382-8. doi:10.1056/NEJMoa2001017
- 3.Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 2020; published online 3 February. doi:10.1038/s41586-020-2012-7
- 4. Jin H, Hong C, Chen S, et al. Consensus for prevention and management of coronavirus disease 2019 (COVID-19) for neurologists. Stroke and Vascular Neurology. 2020;0. doi: 10.1136/svn-2020-000382.
- 5.https://www.who.int/emergencies/diseases/novel-coro- navirus-2019.
- 6. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China 7. Ling Mao; Huijuan Jin; Mengdie Wang; Yu Hu; Shengcai Chen; Quanwei He; Jiang Chang; Candong Hong; Yifan Zhou; David Wang; Xiaoping Miao; Yanan Li, MD, PhD; Bo Hu, MD, PhD
- 8. Giacomelli et al., 2020; Ryan, 2020; Hopkins and Kumar, 2020
- 9.A Novel Angiotensin-Converting Enzyme–Related Carboxypeptidase (ACE2) Converts Angiotensin I to Angiotensin 1-9 Mary Donoghue, Frank Hsieh, Elizabeth Baronas, Kevin Godbout, Michael Gosselin, Nancy Stagliano, Michael Donovan, Betty Woolf, Keith Robison, Raju Jeyaseelan, Roger E. Breitbart, Susan Acton
- 10. Baig AM, Khaleeq A, Ali U, Syeda H. Evidence of the COVID-19 Virus Targeting the CNS : Tissue Distributi- on , Host − Virus Interaction , and Proposed Neurotropic Mechanisms. ACS Chem. Neurosci. 2020, 11, 995−998
- 11.Al-Obaidi ve diğerleri, 2018; Soung ve Klein, 2018).
- 12 Li Y, Fu L, Gonzales DM, Lavi E. Coronavirus neurovirulence correlates with the ability of the virus to induce proinflammatory cytokine sig- nals from astrocytes and microglia. J Virol. 2004;78: 3398-406
- 13.Neurological complications of coronavirus and COVID-19. Carold-artal FJ1 DOI: 10.33588/rn.7009.2020179
- 14.Desforges M, Le Coupanec A, Dubeau P, Bourgouin A,Lajoie L, Dubé M, Talbot PJ. Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? Viruses. 2019;12. pii: E14.
- 15. How viruses infiltrate the central nervous system A. mıchalıcov.1, k. bhıde3, m. bhıde1,3, a. kov.č1,2*
- 16.Ye M, Ren Y, Lv T. Encephalitis as a clinical manifestation of COVID-19. Brain Behav Immun. 2020 Apr 10. pii: S0889- 1591(20)30465-7.
- 17.Moriguchi T, Harii N, Goto J, Harada D, Sug- awara H, Takamino J, et al. A first case of meningitis/encephalitis associated with SARS- Coronavirus-2. Int J Infect Dis. 2020;94:55-8
- 18. COVID-19–associated Acute Hemorrhagic Necrotizing Encephalopathy: CT and MRI Neo Poyiadji, MD, Gassan Shahin, MD, Daniel Noujaim, MD, Michael Stone, MD, Suresh Patel, MD, Brent Griffith, MD
- 19. Acute necrotizing encephalopathy and myocarditis in a young patient with COVID-19 Ahmed Elkady, MSc, and Alejandro A. Rabinstein, MD Neurol Neuroimmunol Neuroinflamm 2020;7:e801. doi:10.1212/NXI.0000000000000801
- 20.Wong PF, Craik S, Newman P, et al. Lessons of the month 1: a case of rhombencephalitis as a rare complication of acute COVID-19 infection. Clin Med (Lond) 2020; published online May 5. https://doi.org.10.7861/clinmed.2020-0182.
- 21) Zanin L, Saraceno G, Panciani PP, et al. SARS-CoV-2 can induce brain and spine demyelinating lesions. Acta Neurochir (Wien) 2020; published online May 4. https://doi.org.10.1007/s00701-020-04374-x.
- 22. Li M, Wang M, Zhou Y, Sapozhnikov S, Dandu V, Toom S. et al. Acute cerebrovascular disease following CO- VID-19 : a single center , retrospective , observational study. The Lancet. 2020;19. Online ahead of print.
- 23. Beyrouti R, Adams ME, Benjamin L, Cohen H, Farmer SF, Goh YY, et al. Characteristics of ischaemic stroke associated with COVID-19. J Neurol Neurosurg Psychiatry. 2020.
- 24. Oxley TJ, Mocco J, Majidi S, Kellner CP, Shoirah H, Singh IP, et al. Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young. N Engl J Med. 2020 May;382(20):e60.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 5 Ağustos 2020 |
| Gönderilme Tarihi | 28 Temmuz 2020 |
| Yayımlandığı Sayı | Yıl 2020 Cilt: 3 Sayı: Özel Sayı |